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Sibutramine information

What is Sibutramine and How does it Work?

Sibutramine is a type of anorectic drug, meaning that it suppresses appetite. It is indicated for weight loss in people who are severely overweight due to overeating. Sibutramine is not unlike amphetamines in terms of structure though the way that it works is significantly different. Instead of stimulating the body, Sibutramine primarily works as a serotonin-norepinephrine reuptake inhibitor (SNRI). Serotonin and norepinephrine are naturally-occurring neurotransmitters in the body which have various functions, including regulating hunger cravings. The neurotransmitters are normally released into the brain and then quickly reabsorbed. By taking Sibutramine, the reabsorption process is hindered, thus causing about twice as much of the neurotransmitters to be available in the brain. This results in feeling of satiation.

Important Information about Sibutramine

A study involving approximately 10,700 people was performed to analyze the safety of Sibutramine. The conclusion of this 6-week study was that Sibutramine is safe for treating obesity including in high-risk patients. However, the study showed that Sibutramine may increase the likelihood of patients having severe heart problems which could be fatal. Of the trial participants taking Sibutramine, 11.4% of them experienced a cardiovascular problem as compared to 10% of participants who were taking a placebo. Because of this increased risk of cardiovascular problems, Sibutramine has been withdrawn from the market in many nations including the US, Canada, European Union, Australia, India, China, and others. Sibutramine is still available in some markets. However, patients who are taking Sibutramine should talk to their doctor about other, safer methods of suppressing appetite for weight loss.

Note about taking Sibutramine

Sibutramine should only be taken as part of a complete plan for weight loss that may also include exercising and eating a healthy diet. No weight-loss or appetite suppressing drug, including Sibutramine, should be used in place of these lifestyle changes for weight loss.

Sibutramine Indications

Sibutramine is indicated for severely overweight patients who have a body mass which is greater than 30 kg/m2 or greater than 27 kg/m2 if they also have certain conditions which are related to obesity (such as high blood pressure or diabetes, amongst others). To calculate your body mass, your weight in kilograms should be divided by your height in meters squared.

Sibutramine Dosing and Administering Information

The advised dosage for Sibutramine is 10 milligrams taken once per day. Sibutramine may be taken without regards to meals. The patient's progress should be reassessed a maximum of four weeks after starting treatment. If the patient has not lost a minimum of four pounds during this time, then dosage may be increased to 15 milligrams taken once per day. However, the doctor may also decide to stop treatment with Sibutramine as studies show patients who do not lose this amount of weight during the first four weeks of treatment are not likely to have significant weight loss during the course of treatment. Patients should be regularly evaluated for adverse effects while taking Sibutramine.

Potential Adverse Effects from Sibutramine

Many patients taking Sibutramine have the following adverse effects which are generally not cause for concern: backache, becoming constipated, feeling woozy, dry mouth, headaches, pains in joints, feeling nauseous, anxiety, pains during menstrual period, cold-like symptoms, insomnia, gastrointestinal disturbances, or feeling weak. These effects usually will go away once your body becomes adjusted to the medicine. You should tell your doctor if they get worse or are continuous. Sibutramine may cause serious or even fatal problems including heart attack, stroke, and liver damage, amongst others. Immediately get emergency medical treatment if you have any of these adverse effects during treatment with Sibutramine: pains in chest/jaw/eyes/left side, sudden confusion, sudden changes to vision, losing consciousness, unexplained changes to mood, feeling numb in limbs, unusual restlessness, convulsions, chronic wooziness, sudden headache, inflammation to extremities, abdominal pains, or symptoms of allergic reaction.

Sibutramine Contraindications

Sibutramine may be contraindicated for these conditions: allergies, hypertension, heart problems, stroke, circulatory problems, you are anorexic or bulimic, impaired kidneys, age under 16 years, or aged over 65 years. It may not be safe for you to use this medicine if you have other health problems or you may need to follow special instructions during treatment. Make sure your doctor is aware of your full medical history. Do not take Sibutramine while pregnant or breastfeeding.

Interactions with Sibutramine

It is crucial that you do not take Sibutramine with certain other drugs or medications as it could cause a severe or deathly interaction. Do not take any drug/medication with Sibutramine without asking your doctor or pharmacist if it is safe to use. These are just some of the drugs which may interact with Sibutramine: other appetite suppressants, other weight-loss drugs, antidepressant drugs, triptan drugs, monoamine oxidase (MAO) inhibitors, blood thinners, antibiotics, lithium, medicine for fungal infections, medicine for psychiatric problems, stimulants (including illicit drugs like cocaine and some amphetamines), MDMA ("ecstasy"), or medicine for heart problems.

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