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Xenical information

Xenical Description and Mode of Action

Xenical is a brand name for the active drug Orlistat. It is a weight-loss drug which is available by prescription or over the counter in some formulations. The way that Xenical works is by inhibiting the actions of certain enzymes which are responsible for breaking down triglyceride fats within the intestines. Instead of being absorbed by the body, these fats are excreted. Part of Xenical's mode of action is aversion therapy because the expulsion of fats can cause gastrointestinal disturbances. Xenical users may come to associate fatty foods with these adverse effects, thus causing them to follow a healthier, low-fat diet and lose weight.

How to take Xenical

Xenical comes in capsule form which is taken orally. Typically, this medicine is taken during meals which contain fats or within one hour of eating such meal. Always take Xenical with a full glass of water. If your meal contains more than 30% of its caloric amount from fats, bothersome gastrointestinal effects could occur. It is advised that you maintain a low-fat, healthy diet while taking Xenical. If you eat a meal which is without fats, then omit that dose of Xenical. Usually, Xenical is taken three times per day. Follow all instructions about how to take Xenical with other medications. Results should be noticeable within two weeks of initiating treatment with Xenical.

Side Effects from Xenical

The most common side effects associated with Xenical are gastrointestinal disturbances such as oily stools, diarrhea, frequent bowel movements, poor control over bowel movements, and gas. These are not serious but may be bothersome to patients. In order to avoid these adverse effects, patients are advised to avoid consuming fatty foods while taking Xenical. It is recommended that a maximum of 15 grams of fat be in meals. In rare cases, Xenical may lead to serious conditions. Immediately contact your doctor if you have these adverse effects from Xenical: signs of liver impairment (brown urine, jaundice, or severe/chronic abdominal pains), signs of kidney stones (severe pain in back, pains during urination, or pinkish urine), or signs of an allergic reaction (skin irritation, feeling like you cannot breathe, or inflammation to facial/oral areas).

What to Know before you take Xenical

Many vitamins are absorbed along with fats, such as vitamins A, D, E and K. Because Xenical infers with the fat-absorption process, you may not absorb the full amount of vitamins from a meal. It is recommended that you take a multivitamin supplement two hours before or after your dosage of Xenical.

Who Should Not Take Xenical

Some patients may not be able to safely take Xenical or may require special dosing instructions or monitoring for adverse effects. Be sure your doctor knows your complete medical history before taking Xenical, especially if you have: allergies, bowel related disorders, gastrointestinal problems, cholestasis, kidney stones, thyroid problems, are anorexic/bulimic, or are diabetic. Diabetics may need to alter their medication while taking Xenical and need to monitor their blood sugar levels with more frequency. Do not use this medicine while pregnant as it could result in harm to your unborn child. It is currently not known if Xenical will pass into breast milk. Do not take this medicine while breastfeeding without first discussing the risks with your doctor.

Interactions with Xenical

It is important that you inform your doctor of all drugs and medicines you may take before beginning treatment with Xenical because a serious interaction could occur. Particularly be sure your doctor knows if you use any of the following: blood thinning drugs, diabetes medicines, immunosuppressant drugs, levothyroxine, antiarrhythmic medicines or certain heart medicines.

Missed Doses of Xenical

If you forget to take your dose of Xenical, you should take it right away but only if no more than 60 minutes has passed since you ate a meal. If more than 60 minutes has already passed, then skip that dose. Never take an extra dose of Xenical to compensate for a missed dose as it could cause adverse effects. Xenical should only be taken with or within 60 minutes of meals with fat. If you miss a meal or have a meal which does not have fats, then you may omit your dosage of Xenical.

What Results to Expect from Xenical?

In clinical studies, Xenical caused approximately 35 to 54 percent of users to have a 5% reduction in body mass. Approximately 16 to 25 percent of users had a 10% reduction in body mass. Not all of this reduction is due to fat however. After users stopped taking Xenical, most of them regained weight but only a maximum of 35 percent of the mass they had lost during treatment. When Xenical is taken in a dosage strength of 120 mg and three times per day as directed, it can prevent about 30 percent of fats from the meal from being absorbed into the body. Dosage strengths of 60 mg prevented about 25 percent of fats from being absorbed. Taking Xenical in large dosage amounts (more than 120 mg) will not cause this drug to be more effective.

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